High resolution

Module 8: Figure PCP in insects and vertebrates

Examples of planar cell polarity (PCP) in insects and vertebrates.

a. The orientation of hairs in a wild-type Drosophila wing. b. A wing carrying a mutation in Frizzled (Fz). c. Normal hair orientation on a mouse paw. d. Hair swirls in a mouse carrying a mutation in Fz6. e. Normal ommatidial orientation in the eye of Drosophila. f. Ommatidial orientation disrupted in a fly carrying a mutation in strabismus (Stbm). g. Normal orientation of stereocilia on hair cells in mouse cochlea. h. Pattern of stereociliary bundles disrupted in Vangl2 mutants. i. and j. Lateral and dorsal views of the zebrafish embryo after convergent extension. j. and l. The same views of a Stbm mutant that failed to extend. Reproduced by permission from Macmillan Publishers Ltd: Seifert, J.R.K. and Mlodzik, M. (2007) Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat. Rev. Genet. 8:126–138. Copyright (2007); http://www.nature.com/nrg; see Seifert and Mlodzik (2007).