High resolution

Module 8: Figure HSC regulation

Regulation of haematopoietic stem cell (HSC) function.

The haematopoietic stem cell (HSC) spends most of its time within the osteoblastic niche where its activity is regulated by a host of stimuli, many of which are held on the surface of the spindle-shaped N-cadherin positive osteoblastic (SNO) cell. Some of these stimuli act to regulate proliferation whereas others determining the mobilization and homing responses (Module 8: Figure bone marrow). BMP, bone morphogenetic protein; CaR, Ca2+-sensing receptor; FGF-4, fibroblast growth factor-4; FGFR, fibroblast growth factor receptor; SCF, stem cell factor;