High resolution

Module 8: Figure ES cell miRNAs

Embryonic stem (ES) cell miRNAs.

The survival and self-renewal of embryonic stem (ES) cells is maintained by a limited number of pluripotency regulatory transcription factors such as Oct4, Sox2, Nanog and Krüppel-like factor 4 (Klf4) (green panel). These regulatory factors use a number of ES cell microRNAs (orange panel) to control the expression of key proteins responsible for the cell-cycle regulatory mechanisms (pink panel). The blue panel at the bottom illustrates some of the microRNA regulatory processes that control differentiation.