High resolution

Module 8: Figure B cell maturation signalling

Affinity maturation of germinal centre B cells.

Affinity maturation of B-cells within the germinal centre (Module 8: Figure germinal centre) depends on interactions with both follicular dendritic cells and follicular helper T-cells (TFH cells). Information is passed between these interacting cells through juxtacrine and paracrine mechanisms as described in the text. This Figure is based on Figure 2 in Vinuesa et al. (2009).