High resolution

Module 8: Figure preosteoclast chemotaxis

Chemotaxis of preosteclasts.

The migration of preosteoclasts in the bone marrow is controlled by two chemotaxis gradients. CXCL12 produced by stromal cells and osteoblasts directs cells towards the bone surface where they differentiate into osteoclasts whereas sphingosine-1-phosphate (S1P) directs them back into the blood stream.