High resolution

Module 8: Figure meiotic Ca2+ signalling

Ca2+ signalling during the acquisition of meiotic competence

Ca2+ oscillations recorded at different stages of mouse oocyte maturation. (A) Oocytes isolated from 13-day-old mice were quiescent. (B) Oocytes from 16-day-old mice began to show transients, but with very low frequencies. (C) In fully grown competent oocytes from mice at 23 days, regular Ca2+ oscillations were recorded that spiked with a frequency of approximately 1 min. Reproduced from Carroll, J., Swann, K., Whittingham, D. and Whitaker, M. (1994) Spatiotemporal dynamics of intracellular [Ca2+]i oscillations during the growth and meiotic maturation of mouse oocytes. Development 120:3507–3517, with permission from The Company of Biologists; see Carroll et al. 1994.