Module 8: Figure Satellite cell activation
Control of Satellite cell proliferation and differentiation.
Activation of the quiescent satellite cell to begin its rounds of proliferation and subsequent differentiation is driven by a number of stimuli. Hepatocyte growth factor (HGF), fibroblast growth factor (FGF) and Delta-1 play a primary role in promoting proliferation. Proliferation is inhibited by TGF-β growth factors including myostatin (GDF8) and by Numb, which inhibits the Notch signalling pathway. Insulin-like growth factor (IGF) has complex actions on both proliferation and differentiation. M-cadherin contributes to differentiation by promoting the expression of both IGF and protein kinase B (PKB).