High resolution

Module 7: Figure skeletal muscle E-C coupling

Skeletal muscle control mechanisms of contraction and energy metabolism.

A number of different signalling pathways co-operate to regulate the activity of skeletal muscle contraction and metabolism. The processes of excitation–contraction (E-C) coupling is the sequence of events that transduce the electrical signal arriving via the motor neurons into the Ca2+ signal that triggers contraction (Steps 1–5). The supply of energy is increased both by Ca2+ (Step 7) and by the adrenaline-induced activation of the cyclic AMP signalling pathway (Steps 6–8). Insulin promotes energy storage by stimulating glycogen synthesis (Steps 9–13).