High resolution

Module 7: Figure melanogenesis

Keratinocyte-melanocyte interactions during melanogenesis.

In response to UV irradiation, keratinocytes release stimuli such as α-MSH and SCF that act in a paracrine manner to stimulate melanogenesis by the melanocytes. The sequence of events (1–12) that occur during melanogenesis are described in the text. Adrenocorticotropic hormone (ACTH); ETB, endothelin receptor B: ET-3, endothelin-3; MC1R, melanocortin-1 receptor; α-MSH, α-melanocyte-stimulating hormone; MITF, microphthalamia-associated transcription factor; PAR3, proteinase-activated receptor 3; Pax3, paired box 3; POMC, pro-opiomelanocortin; SCF, stem cell factor; SOX10, sex-determining region Y (SRY)-box 10; TYR, tyrosinase; TYRP1, tyrosinase-related protein 1; TYRP2, tyrosinase-related protein 2.