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Module 7: Figure lipolysis and lipogenesis

Hormonal regulation of lipogenesis and lipolysis in white fat cells.

The process of lipolysis, which is shown on the right side of the figure, is controlled by hormones such as noradrenaline (norepinephrine; NE), adrenocorticotrophic hormone (ACTH) and glucagon. The action of these hormones is mediated by the cyclic AMP signalling pathway. The lipogenic action of insulin is carried out by the PtdIns 3-kinase signalling pathway that stimulates the activity of phosphodiesterase PDE3B, which thus removes cyclic AMP and reduces the ability of this signalling pathway to promote lipolysis.