High resolution

Module 7: human uterine contractions

Spontaneous contractions of human uterine smooth muscle.

Strips of human smooth muscle respond to oxytocin by a marked acceleration in the rhythmic contractions. Each contraction is driven by transient pulses of Ca2+ measured with the indicator Indo-1. Upon addition of cyclopiazonic acid (CPA), the basal level of Ca2+ increased and the oscillator continued. Oscillations ceased immediately after adding 10 μM nifedipine that inhibits Ca2+ entry through VOCs. Reproduced from Kupittayanant et al. (2002).