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Module 7: Figure hepatic stellate cell

Hepatic stellate cell function.

The hepatic stellate cells are characterized by a large deposit of lipid droplets containing vitamin A. They are normally quiescent but are strongly activated during liver injury when they respond to a variety of stimuli released from damaged cells. The hepatic stellate cells undergo a process of phenotypic remodelling during which they lose their lipid (retinoid droplets) and are transformed to carry out a variety of functions that include proliferation, contraction, fibrogenesis and inflammation.