High resolution

Module 7: Figure bladder Ca2+ wave



Spatiotemporal patterns of Ca2+ signals in mouse bladder smooth muscle cells.

Mouse bladder smooth muscle cells voltage clamped at −60 mV were depolarized to 0 mV for 30 ms. The spatial characteristic of the Ca2+ signal recorded with fluo-4 is shown under control conditions (Aa) or in the presence of 100 μM ryanodine to block Ca2+ release from the ryanodine receptors (Ba). In panels b, the black line is the current trace, the red and green traces record Ca2+ at sites α and β near the membrane whereas the blue trace records Ca2+ over the whole cell. Reproduced from Morimura et al (2005).