High resolution

Module 7: Figure atrial arrhythmias

Modulation of atrial cell contractility.

Responses of electrically paced atrial cells to digoxin (1 μM), endothelin-1 (ET-1; 0.1 μM) and isoproterenol (Iso; 0.1 μM). The black arrowheads indicate when the electrical stimulation was applied. The pre-application recordings on the left illustrate the regular control Ca2+ transients. The recordings on the right are responses 15 min after applying the different agents. From MacKenzie, L., Bootman, M.D., Laine, M., Brig, J., Thuring, J., Holmes, A., Li, W.-H. and Lipp, P. (2002) The role of inositol 1,4,5-trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes. J. Physiol. 541:395–409, with permission from Blackwell Publishing; see MacKenzie et al. 2002.)