High resolution

Module 7: Figure astrocyte organization

The structure and arrangement of astrocytes.

a. The stellate organization of astrocytes is illustrated in the enhanced green fluorescent protein (eGFP)-expressing astrocyte shown on the left. Note the foot processes on the surface of the blood vessel. In the section on the right, astrocytes have been stained with an antibody against the glial fibrillary protein (GFAP), which picks out the main branches. The outline of each cell has been drawn in as transparent polyhedra to illustrate that there is very little overlap between the individual astrocytes. The blood vessels run in between the columns of astrocytes. For details of the relationship between the astrocytes and the blood vessels, see Module 7: Figure astrocyte structure. Reproduced from Trends Neurosci., Vol. 26, Nedergaard, M., Ransom, B and Goldman, S.A., New roles for astrocytes: redefining the functional architecture of the brain, pp. 523–530. Copyright (2003), with permission from Elsevier; see Nedergaard et al. 2003.