High resolution

Module 7: Figure smooth muscle cell cyclic GMP signalling

Function of the nitric oxide (NO)/cyclic GMP signalling pathways in controlling relaxation of smooth muscle cells.

Nitric oxide (NO) acts on the soluble guanylyl cyclase (sGC) to form cyclic GMP (cGMP), which acts through a number of targets to dampen both the Ca2+- and Rho-dependent signalling mechanisms that induce contraction by increasing the phosphorylation of the myosin light chain attached to the myosin.