High resolution

Module 7: Figure InsP3-induced arrhythmias



Inositol trisphosphate (InsP3)-induced arrhythmias in atrial myocytes.

The arrowheads represent the times when the cells were depolarized. a. There was no change in the control cells recorded after 2 and 5 min. b. The cells treated with 10 μM InsP3BM, which is a membrane-permeant inositol 1,4,5-trisphosphate (InsP3) ester, began to develop arrhythmias. By 5 min, the spontaneous Ca2+ transients were as large as those induced by electrical stimulation. Reproduced from Curr. Biol., Vol. 10, Lipp, P., Laine, M., Tovey, S.C., Burrell, K.M., Berridge, M.J., Li, W.-H. and Bootman, M.D., Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart, pp. 939–942. Copyright (2000), with permission from Elsevier; see Lipp et al. 2000.