Module 7: Figure ICC tissue location
Location of ICC in the guinea-pig gastrointestinal tract.
Immunohistochemical techniques were used to locate ICCs (green fluorescence) and nerves (red fluorescence). a. A network of ICC-MY located in the myenteric plexus of the small intestine. Some of the ICC are closely associated with the regular neural network. b. Most of the ICC-IM run along the smooth muscle cells orientated in the horizontal direction. A few ICC-IM in the longitudinal muscle are shown running in the perpendicular direction. c. ICC-IM closely associated with nerve tracts located in the circular muscle of the small intestine. d. ICC-CM located in the corpus region of the stomach. Note how many of the ICC-IM run in parallel with nerve fibres. Reproduced from Komuro (2006).