High resolution

Module 7: Figure ICC slow waves

Simultaneous recording of Ca2+ transients and membrane potential slow waves.

The intracellular Ca2+ transients (red trace) recorded in urethral cells coincide with the slow wave fluctuations in membrane potential (blue trace). Pacemaker activity continued in the presence of nifedipine that inhibits voltage-operated Ca2+ channels. The brief depolarizations that precede each slow wave correspond to the Ca2+-dependent spontaneous transient inward currents (STICs) shown in Module 7: Figure ICC pacemaker. Reproduced from Seargent et al. (2006).