High resolution

Module 7: Figure osteoclast podosome

Structure and regulation of the osteoclast podosome.

The osteoclast undergoes periodic changes in its functional activity. It can migrate rapidly over the bone surface until it finds a site where it begins to attach and spreads out to form the polarized bone resorbing cell. The podosomes (dashed box), which are used by migrating cells and by cells as they spread on to the bone surface, contain the actin remodelling proteins and associated signalling components that are responsible for the periodic processes of actin assembly and disassembly. The activation and function of the highly polarized resorbing cell is shown in Module 7: Figure osteoclast function. See the text for further details.