High resolution

Module 7: Figure osteoclast function

Control of osteoclast-dependent bone resorption.

The mature osteoclast is a polarized cell that functions to dissolve the bone matrix to form a resorption pit. The early phases of attaching to the bone surface through a podosome is shown on the left (Steps 1 and 2), whereas the more structured attachment site with its tight seal and actin ring is shown on the right (Step 3). Both the early and later attachment sites are controlled by integrin signalling. The different steps are described in more detail in the text.