High resolution

Module 7: Figure osteoblast function

Osteoblast function in bone formation.

Bone formation is regulated by a large number of signalling pathways. The Wnt signalling pathway acts through β-catenin to control the proliferation and differentiation of the osteoblasts. The insulin-like growth factor 1 (IGF-1) acts through the PtdIns 3-kinase pathway to promote survival of the osteoblasts. The cyclic AMP signalling pathway, which is activated or inhibited by different agonists regulates the expression of the extracellular matrix components such as collagen I and osteocalcin responsible for bone formation.