High resolution

Module 7: Figure neuronal chemokine function

Neuronal–microglia chemokine signalling interactions.

Neurons and microglia interact with each other within both the peripheral and central nervous systems. Much of this interaction is carried out by chemokines and both cell types not only synthesize and release chemokines but they can also respond to them thus setting up a two-way interacting network that has led to the development of a hypothesis to explain the neuronal sensitization responsible for neuropathic pain.