High resolution

Module 7: Figure airway cell oscillations

Ca2+ control of ciliary beat frequency (CBF) in airway epithelial cells.

When the ciliary beat frequency (CBF) (black line) and intracellular Ca2+ concentration ([Ca2+]i) (shown in red) were measured simultaneously, there was a tight coupling between these two parameters. In response to the non-metabolizable ATP analogue adenosine 5´-[γ-thio]triphosphate (ATPγS), the [Ca2+]i was found to oscillate. The three panels illustrate that when the frequency increased as the concentration of ATPγS increased, there was a parallel change in CBF. Reproduced from Zhang, L. and Sanderson, M.J. (2003) Oscillations in ciliary beat frequency and intracellular calcium concentration in rabbit tracheal epithelial cells induced by ATP. J. Physiol. 546:733–749, with permission from Blackwell Publishing; see Zhang and Sanderson 2003.)