High resolution

Module 7: Figure L cell

Control of L cell secretory function.

L cells are enteroendocrine cells located in the wall of the intestine where they function to release various gut hormones such as peptide YY (PYY) and glucagon-like peptide 1 (GLP-1). Acetylcholine on the basal side or nutrients in the lumen act on G protein-coupled receptors to induce the formation of inositol 1,4,5-trisphosphate that then releases Ca2+ to trigger hormone release. The neighbouring intestinal cells function in nutrient absorption and fluid secretion (Module 7: Figure intestinal secretion).