High resolution

Module 6: Figure vinculin function

Proposed role of vinculin in stabilizing focal adhesion complexes.

Vinculin exists in two main states: an auto-inhibited state, where the Vt domain bends round to interact with the N-terminal D1 and D3 regions, and an activated state, where the molecule opens out to unveil binding sites for many of the components of the adhesion complex. By interacting with different components, vinculin functions to stabilize the complex. For simplicity, most of the other adhesion molecules have been left off. A more detailed picture is shown in Module 6: Figure integrin signalling.