High resolution

Module 6: Figure signalling hierarchies

The spatial organization of signalling pathways.

The way in which information is transferred in cells is often highly organized, as illustrated in this highly schematic depiction of how components of signalling pathway are organized. A. The basic components of a typical signalling pathway, consisting of a receptor (R) and three signalling components (X, Y and Z). B. In those cases where the signalling components are proteins, information is transmitted through protein–protein interactions using signal transduction domains. For example, a motif on protein X recognizes a specific binding site on protein Y and so on. C. A variety of scaffolds function to hold together the individual components of signalling pathways to create macromolecular signalling complexes. D. These macromolecular signalling complexes can be aggregated in specific locations within the cell, as occurs in lipid rafts and caveolae.