High resolution

Module 6: Figure liver intercellular Ca2+ wave

An intercellular Ca2+ wave recorded in the intact liver.

The intact liver was loaded with the Ca2+ indicator Fluo3, which showed up the sheets of liver cells in a number of lobules. When the liver was perfused with vasopressin, Ca2+ signals originated in the periportal (PP) regions and then moved out as an intercellular wave towards the pericentral (PC) regions. Reproduced from Robb-Gaspers, L.D. and Thomas, A.P. (1995) Coordination of Ca2+ signalling by intercellular propagation of Ca2+ waves in the intact liver. J. Biol. Chem. 270:8102–8107, with permission from the American Society for Biochemistry and Molecular Biology; see Robb-Gaspers and Thomas 1995.