High resolution

Module 6: Figure integrin signalling

Structural and signalling functions of integrins within the focal adhesion complex.

Integrins provide an anchor for attaching actin to the plasma membrane. Attachment of actin to the cytoplasmic domain of the integrin β-subunit depends upon a number of proteins such as α-actinin, filamin, paxillin, talin and vinculin. The integrin receptor also assembles a number of signalling components for the mitogen-activated protein kinase (MAPK) pathway, the PtdIns 3-kinase signalling pathway and the guanine nucleotide exchange factors (GEFs) such as α-Pix and downstream of Crk-180 homologue (DOCK) that activate G proteins such as Rac and Cdc42 to initiate actin assembly. This signalling aspect depends on two main kinases: focal adhesion kinase (FAK) and integrin-linked kinase (ILK), which are shown separately to simplify the diagram.