High resolution

Module 6: Figure caveolae organization

The organization and signalling function of lipid rafts and caveolae.

The rafts and caveolae are specialized regions of the plasma membrane (green zones), which are characterized by having a lipid composition (particularly rich in cholesterol and sphingomyelin) distinct from that of the remaining plasma membrane. Apart from its distinct shape, the caveolus differs from the raft by having a cytoplasmic coat of caveolin molecules (yellow). These specialized regions of the plasma membrane contain a number of signalling components (receptors, transducers, channels, pumps and exchangers) responsible for initiating many of the major cell signalling pathways.