Module 6: Figure cadherin superfamily
Cadherin superfamily of cell–cell adhesion molecules.
Most of the cadherins are single-membrane-spanning proteins characterized by having large extracellular domains containing multiple Ca2+-binding extracellular cadherin (EC) domains (shown in green). The exception is the Drosophila cadherin called Flamingo and its mammalian homologues Celsr1–Celsr3, which have seven membrane-spanning regions. The way in which some of these cadherin interact with each other during cell signalling is shown in Module 6: Figure classical cadherin signalling and in Module 8: Figure planar cell polarity signalling.