Module 6: Figure activity rhythms in Cx36−/− mice
Suprachiasmatic nucleus (SCN) neuronal synchronization is lost in mice deficient in the gap junction component Cx36.
Coupling between wild-type (WT) neurons maintains a regular diurnal rhythm, as measured by wheel-running activity as shown in blue at the bottom. Each bar represents the activity over a 24 h period, with each plotted from the top to the bottom. In the Cx36−/− mice, neuronal coupling is lost and the diurnal rhythm (shown in red) becomes much more chaotic. Reproduced by permission from Macmillan Publishers Ltd: Nat. Neurosci., Colwell, C.S. (2005) Bridging the gap: coupling single-cell oscillators in the suprachiasmatic nucleus. 8:10–12. Copyright (2005); http://www.nature.com/neuro; see Colwell 2005.