High resolution

Module 6: Figure SCN cytosolic Ca2+ oscillation

Simultaneous recording of Ca2+ oscillations and neural electrical activity rhythms in suprachiasmatic nucleus (SCN) neurons.

A Ca2+-sensitive fluorescent protein was used to monitor the intracellular level of Ca2+ (red dots), while electrical activity was recorded using a microelectrode array (black trace). The two responses had a similar wave form, but the Ca2+ trace was advanced by about 4 h. Reproduced from Neuron, Vol. 38, Ikeda, M., Sugiyama, T., Wallace, C.S., Gomp, H.S., Yoshioka, T., Miyawaki, A. and Allen, C.N., Circadian dynamics of cytosolic and nuclear Ca2+ in single suprachiasmatic nucleus neurons, pp. 253–263. Copyright (2003), with permission from Elsevier; see Ikeda et al. 2003.