High resolution

Module 6: Figure caveolae molecular organization

A schematic diagram to illustrate how caveolin is thought to organize various signalling components.

The caveolin molecules that oligomerize with each other are embedded in the membrane through a hydrophobic region. Another region that is close to this hydrophobic domain has the caveolin scaffolding domain (shown in black). A number of signalling components have caveolin-binding motifs (shown in red), which enable them to associate with this scaffolding region.