Cell Signalling Biology
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Please cite as Berridge, M.J. (2011) Cell Signalling Biology; doi:10.1042/csb0001006
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Ca2+ oscillation model
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Module 6: Figure Ca2+ oscillation model (animated)
A model to explain agonist-dependent Ca2+ oscillations.
The emphasis of this model is that oscillations depend upon the accumulation of Ca2+ within the lumen of the endoplasmic reticulum (ER), which then sensitizes the inositol 1,4,5-trisphosphate (InsP3) receptors to initiate each spike. Oscillation frequency is thus determined by the rate at which the lumen is loaded with Ca2+, which in turn is determined by the agonist-dependent rate of Ca2+ entry across the plasma membrane. The sequences of events that occur during a typical oscillatory cycle are described in more detail in the text.

Original figure