Please cite as Berridge, M.J. (2011) Cell Signalling Biology; doi:10.1042/csb0001006
A model to explain agonist-dependent Ca2+ oscillations.
Module 6: Figure Ca2+ oscillation model (animated)
The emphasis of this model is that oscillations depend upon the accumulation of Ca2+
within the lumen of the endoplasmic reticulum (ER), which then sensitizes the inositol 1,4,5-trisphosphate (InsP3
) receptors to initiate each spike. Oscillation frequency is thus determined by the rate at which the lumen is loaded with Ca2+
, which in turn is determined by the agonist-dependent rate of Ca2+
entry across the plasma membrane. The sequences of events that occur during a typical oscillatory cycle are described in more detail in the text.