Module 6: Figure classical cadherin signalling
Classical cadherin cytoskeletal and signalling functions.
Classical cadherins on neighbouring cells interact with each through their extracellular cadherin (EC) domains. The cytoplasmic domain interacts with both p120 catenin, which has a regulatory role by interacting with signalling components such as Fer and the p190RhoGAP that controls G protein signalling, and β-catenin. The latter provides a link to the cytoskeleton through its interaction with α-catenin.