Module 6: Figure cardiac caveolae

Caveolae in rat cardiac ventricular cells.

In the freeze–fracture image shown at the top, there are numerous openings of the caveolae (yellow arrows) in the membrane between the T-tubule invaginations. In the tangential section shown at the bottom, the caveolae have different shapes – rounded, dumb-bells (green) or trilobed (yellow) – and are surrounded by a network of the sarcoplasmic reticulum (red arrows). Reproduced from J. Ultrastruct. Res., Vol. 65, Gabella, G., Inpocketings of the cell membrane (caveolae) in the rat myocardium, pp. 135–147. Copyright (1978), with permission from Elsevier; see Gabella (1978).