Module 6: Figure NFAT nuclear translocation
The effect of Ca2+ oscillation frequency on the nuclear translocation of nuclear factor of activated T cells (NFAT).
(A) Recordings of the Ca2+ oscillations that were used to study the nuclear translocation of nuclear factor of activated T cells (NFAT). (B) When these oscillations were applied to cells, the low-frequency oscillations had little effect, but translocation increased progressively as oscillation frequency was increased. The way in which NFAT translocation was measured is described in Module 4: Figure NFAT translocation. Reproduced by permission from Macmillan Publishers Ltd: EMBO J., Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F. and Iino, M. (2003) NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. 22:3825–3832. Copyright (2003); http://www.embojournal.org; see Tomida et al. 2003.