Module 6: Figure Cbl structure
Structure of the Cbl family of adaptor proteins.
The c-Cbl and Cbl-b isoform are closely homologous. The Cbl-3 isoform resembles the other two in its N-terminal region, but is missing the C-terminal regions. The double-headed arrows illustrate the ability of c-Cbl to interact with a large number of signalling components. Many of these interactions are also evident for Cbl-b. See the text for a description of the abbreviations.