Module 5: Figure structure of the SHPs

Structural organization of the Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases (SHP-1 and SHP-2).

The two mammalian Src homology 2 (SH2) domain-containing protein tyrosine phosphatases (SHPs) have very similar structures. The main features are the PTP domain and the two N-terminal SH2 domains. The C-terminal region has two tyrosine (Y) residues, which in the case of SHP-2 are separated by a prolyl-rich domain.