High resolution

Module 5: Figure mitochondrial Ca2+ oscillations

Mitochondrial tracking of cytosolic Ca2+ transients in hepatocytes.

Hepatocytes stimulated with phenylephrine (PE) generate repetitive Ca2+ transients (lower trace, [Ca2+]c). The Ca2+ concentration in the mitochondria (upper trace, [Ca2+]m) closely tracked the cytosolic oscillation. Reproduced from Biochim. Biophys. Acta, Vol. 1366, Robb-Gaspers, L.D., Rutter, G.A., Burnett, P., Hajnóczky, G., Denton, R.M. and Thomas, A.P. (1998) Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism, pp. 17–32. Copyright (1998), with permission from Elsevier; see Robb-Gaspers et al. 1998.