High resolution

Module 5: Figure PDE domains

Domain structure of the phosphodiesterase (PDE) family that functions to hydrolyse and inactivate the second messenger cyclic AMP.

Many of the phosphodiesterase (PDE) family members are characterized by having paired regulatory domains in the N-terminal regulatory region. PDE1 has Ca2+/calmodulin-binding domains; PDE2, PDE5, PDE6, PDE10 and PDE11 have cyclic GMP-binding GAF domains; PDE4 has upstream conserved regulatory regions 1 and 2 (UCR1 and UCR2). Reproduced from Handbook of Cell Signaling, Vol. 2, Glick, J.L. and Beavo, J.A., Phosphodiesterase families, pp. 431–435. Copyright (2003), with permission from Elsevier; see Glick and Beavo 2003.