Module 5: Figure mitochondrial biogenesis

Mitochondrial biogenesis.

The peroxisome-proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) plays a central role in co-ordinating the activity of the transcription factors such as NRF-1, NRF-2, ERRα and PPARα that control the expression of the numerous components necessary for mitochondrial biogenesis. Nicotinamide–adenine dinucleotide (NAD+) acts to regulate the activity of the transcription factor Myc that also functions in regulating mitochondrial biogenesis. The idea and information for this Figure was taken from Figures 5 and 9 in Scarpulla (2008).