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Module 5: Figure cardiolipin

Cardiolipin formation and oxidation.

Following its synthesis at the inner mitochondrial membrane (IMM), the nascent cardiolipin (CL) is remodelling by the enzyme taffazin, which exchanges the saturated fatty acids with unsaturated fatty acids. The latter are particularly susceptible to peroxidation by reactive oxygen species. This oxidation can be protected by melatonin. The CL provides a membrane niche that facilitates electron flow, it tethers cytochrome c to the IMM and it facilitates the ATP/ADP carrier (AAC). Peroxidation of CL greatly reduces these key mitochondrial processes. Oxidized CL also moves to the OMM where it interacts with Bak and Bax to form pores to allow cytochrome c to escape into the cytoplasm. The Information for this Figure was taken from Osman et al. (2011).