Cell Signalling Biology
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Please cite as Berridge, M.J. (2011) Cell Signalling Biology; doi:10.1042/csb0001005
SERCA pump cycle
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Module 5: Figure SERCA pump cycle (animated)
Functional operation of the sarco/endo-plasmic reticulum Ca2+-ATPase 1a (SERCA1a) pump.
The main domains of the sarco/endo-plasmic reticulum Ca2+-ATPase 1a (SERCA1a) pump concerned with pumping are the nucleotide-binding domain (N), the phosphorylation domain (P), the actuator domain (A) and the transmembrane domains (M1–M10). The molecular events involving these domains are described in the text by reference to the transition states of the pump cycle. Reproduced by permission from Macmillan Publishers Ltd: Nature, MacLennan, D.H. and Green, N.M. (2000) Structural biology: pumping ions. 405:633–634. Copyright (2000); http://www.nature.com; see MacLennan and Green 2000.

Original figure