Module 5: Figure phospholamban mode of action



Phospholamban (PLN) operates within the plane of the sarcoplasmic reticulum (SR) membrane to regulate the activity of the sarco/endo-plasmic reticulum Ca2+-ATPase 2a (SERCA2a) pump.

Phospholamban (PLN) operates in the plane of the sarcoplasmic reticulum, where it acts to regulate the activity of the sarco/endo-plasmic reticulum Ca2+-ATPase 2a (SERCA2a) pump. PLN has five distinct functional states, as described in the text.