Module 5: Figure mitochondrial motility
Control of mitochondrial motility by Ca2+: a working hypothesis.
When Ca2+ concentrations are low, mitochondria are pulled along microtubules by kinesin motors. Proteins such as Milton and Miro attach mitochondria to the kinesin motor. The latter is important for Ca2+ control, because it contains two EF-hands. The microdomains of Ca2+ formed around channels like the inositol 1,4,5-trisphosphate receptor (InsP3R) or the ryanodine receptor (RYR) activate Miro, which then induces the motors to detach from the microtubules thus depositing the microchondria in regions of high Ca2+ concentration.