Module 4: Figure scission of endocytic vesicles
Endocytic vesicle scission and removal of the clathrin coat.
Once the clathrin-coated pit has formed, the neck is cut off to release the vesicle into the cytoplasm. The sequence of events responsible for scission remains to be established. This Figure attempts to illustrate the structural organization of some of the major components responsible for scission. Once the vesicle is formed, the clathrin coat is removed by an ATP-dependent process activated by Hsc70. See the text for further details.