High resolution

Module 4: Figure p62 function

p62 function.

p62 is a multifunctional protein. Its expression is controlled by nuclear factor erythroid 2 related factor 2 (NRF-2) and it then feeds back to enhance the stability of NRF-2 by inhibiting Keap1, which directs it towards proteasomal degradation (Module 4: Figure NRF-2 antioxidant function).