High resolution

Module 4: Figure p53 domains

The domain structure and post-translational modification sites of the transcription factor p53.

The major domains of p53 consist of an N-terminal transactivation domain (TAD), followed by a Src homology 3 (SH3)-like domain. In the middle of the molecule there is a large DNA-binding domain (DBD). The C-terminal region has a nuclear localization signal (NLS), a tetramerization domain (TET) and a regulatory (REG) domain. There are a large number of post-translational sites that are modified by phosphorylation (P), acetylation (A), sumoylation (S) and neddylation (Nd) by a large number of signalling pathways. (See the text for a description of the different enzymes.)